clinical resolution hyaluronic peptide serum in a 1oz white dropper bottle
Key Features +
  • Sodium DNA (PDRN), Platycladus Orientalis Leaf Extract, Laminaria Digitata Extract: A revitalizing marine and botanical complex enriched with antioxidant-rich extracts that help condition and protect the skin from visible environmental stressors. 
  • Hydrolyzed Hyaluronic Acid: A low–molecular weight hyaluronic acid that helps provide rapid hydration, improve skin comfort, and support a smooth, supple appearance. Its smaller structure offers enhanced moisture absorption for a refreshed, balanced-looking complexion.
  • Panthenol (Vitamin B5): A powerful humectant that helps replenish and soothe the skin, leaving it feeling soft, smooth, and hydrated. 
  • Centella Asiatica (Cica) Leaf Vesicle Exosome: A plant-based vesicle technology inspired by exosome science, featuring soothing and antioxidant properties that help comfort the skin and maintain a balanced, hydrated appearance.
  • Malus Domestica Fruit Cell Culture Extract: A plant-derived stem cell extract that helps maintain the appearance of youthful, revitalized skin.
  • rBoost™ NAD+ (Water, Betula Alba Juice, Glycerin, Niacinamide, Sodium Hyaluronate, Nicotinamide Adenine Dinucleotide): A next-generation bioactive complex that helps brighten and hydrate for a revitalized,    energized-looking complexion.
  • Advanced Peptide Complex (Acetyl Hexapeptide-8, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-37, Tripeptide-1): A synergistic blend of next-generation peptides that helps minimize the appearance of fine lines and uneven skin, and visibly improve firmness, elasticity, and smoothness for a youthful-looking complexion.
  • Inulin: A natural prebiotic derived from chicory root and agave that helps protect against environmental stressors and free radicals. 
  • Rice Ferment Filtrate (Sake): A nutrient-rich ferment that helps enhance hydration and promote a radiant appearance.
  • Magnesium Ascorbyl Phosphate (Vitamin C derivative), Dextran, and Nonapeptide-1: Works together to support overall brightness and clarity, and improve the appearance of uneven tone. This synergistic complex supports a more radiant, and balanced-looking complexion while providing antioxidant protection against daily stressors.
Directions +
Apply a liberal amount to cleansed face and neck, morning and night.
Caution +
For external use only. Avoid contact with eyes and mucous membranes.
Full Ingredients +
Water, Aloe Barbadensis Leaf Juice, Niacinamide, Propanediol, Butylene Glycol, Glycerin, Panthenol, Phenoxyethanol, Sodium Hyaluronate, Malus Domestica Fruit Cell Culture Extract, 1,2-Hexanediol, Disodium EDTA, Hydrolyzed Hyaluronic Acid, Betula Alba Juice, Pentylene Glycol, Rice Ferment Filtrate (Sake), Camellia Sinensis, Xanthan Gum, Laminaria Digitata Extract, Platycladus Orientalis Leaf Extract, Ethylhexylglycerin, Nicotinamide Adenine Dinucleotide, Lecithin, Sodium DNA, Centella Asiatica Leaf Vesicles, Inulin, Magnesium Ascorbyl Phosphate, Palmitoyl Tripeptide-37, Polysorbate 20, Tripeptide-1, Acetic Acid, Potassium Sorbate, Acetyl Hexapeptide-8, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Dextran, Nonapeptide-1

Frequently Asked Questions

Who is this serum best suited for? +

This serum is suitable for all skin types, including sensitive and dry skin, as it provides deep hydration, soothes irritation, and supports skin elasticity.

Can I use this serum with other skincare products? +

Yes, this serum can be layered with other skincare products like moisturizers, sunscreens, and serums, but avoid combining it with strong exfoliants or acids in the same routine to prevent irritation.

How often should I use this serum? +

For best results, apply the serum twice daily: once in the morning and once at night, on clean skin before moisturizing.

Will this serum help with fine lines and wrinkles? +

Yes, the formula contains peptides and EGF, which help stimulate collagen production, improve skin firmness, and reduce the appearance of fine lines and wrinkles over time.

  • 5 stars: 43 (83%)
  • 4 stars: 9 (17%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
R
Raina S. (United States)
Medical esthetician here

Medical esthetician here and this serum is ultra hydrating and saw a difference in my fine lines being filled in with their peptide solution!

D
Diane

Quality

S
Stamp C.
No negative issues with my sensitive skin and I feel like my skin looks better

I have enjoyed having this product in my daily routine for a while now. I have sensitive skin and haven't any negative issues. I use this sparingly on damp skin. My skin has a nicer appearance. It isn't an overnight fountain of youth, but with consistent use, I do feel like my skin looks healthier.

M
MAX
A Good All Around Topical Hyaluronic Serum

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Hyaluronic acid serums and creams are hot commodities today. The fact is they contain certain properties in their molecular structures that are beneficial to ageing skin and wrinkles serving as an effective antioxidant and nutrient is a game changer in the facial care industry. My wife as a licensed professional in her respective industry has seen technological advances with usage of topical hyaluronic products. She is light complexion with slight hairline wrinkles around her eyes and forehead. You can use base foundation to hide them, but she believes in using products that can actually reduce wrinkles and tighten the skin thereby using less foundation and makeup giving her more of a natural appearance. This serum by Clinical Resolution does a good job in achieving her objectives. She uses this product once in the morning on clean skin. A couple of drops is all that is needed. It is gently massaged in to the areas of concern. What she has noticed about this product is that you must let in sink into the skin allowing it to be absorbed prior to adding any kind of makeup. She keeps her makeup to the bare minimum therefore retaining a youthful natural and glowing look. You get 1OZ of product sufficient to last many months of daily applications. Results are visible after 3-4 weeks of use. She then uses this serum 2-3 times a week to conserve it. Overall, it has served the purpose quite well. She likes this serum a lot and has incorporated it into her weekly facial maintenance routine. It is value priced. Recommended.

J
JustMe
Gorgeous skin, starts working in a matter of weeks.

I've been using this product for weeks now and to be honest, I wasn't sure if it was even working for me but then one random day out of the blue I started getting asked for my ID for age verification at grocery stores and restaurants. It wasn't just a one time event, it kept happening over and over again and I hadn't been asked for that in like 10 years! What a pleasant surprise this truly has been. So i started paying closer attention after that started happening and realized that this product really does give me a softer and more even skin glow. My skin feels silky to the touch and significantly smoother throughout the entire day. The way I apply is after a fresh washing of my face (both morning and evening), i take a teeny tiny dot of my usual moisturizer then 1-2 dropperfuls of this hyaluronic acid...mix it up in my palm and quickly apply to face and neck. I then let my face dry completely and apply another thick layer of moisturizer to seal it in. I haven't had any issues with this method. No breakouts, no redness, no bumps or rashes. I'm only getting this very silky smooth skin that retains moisture much better than before. I believe that I now have better moisture retention in my skin which is what has caused the very fine lines to completely go away. This product is very reasonably priced as it absolutely works as intended. I wouldn't hesitate to buy again and I would highly recommend it.

P
Patricia P. (United States)
Amazing product !!

I’ve been using this serum in my treatment room and it leaves the skin deeply hydrated, smooth, and healthy-looking. It absorbs quickly and feels amazing!

C
ControlFreak
Fingers Crossed for this Serum!

I�ve been hearing about these Hyaluronic serums for a while, including from my dermatologist. Especially when they are combinations of Hyaluronic Acid, Peptide Serums and Vitamin C. I�m in no way a beauty expert, except for the fact that time has been marching across my face and neck for a few years now and I would love to find something that does not require a scalpel to mask or correct it! ??In order to give an accurate review, it will simply take time for it to work and more research to assess the actual ingredients. Some manufacturers and studies suggest that these serums could take up to 3 months of consistent use to see obvious results. April 19th was my first day of use, and given the cost of these, I�m only going to concentrate on a silver dollar spot right in the middle of my neck�so I�m not having to get another bottle in a month to treat everything and continue my test. I�m setting reminders to get photos every month looking for results. In fairness, I saw a clear difference about an hour later in my fine lines after it had time to absorb. But I also have other products that will do that and it fades away in around 8 hours.Some reviewers have commented about the cost of this product. But in my Amazon search for similar products, I�ve only found products $50 and under that contain only 1 or 2 of the 3 things listed above that I�m after. It gets to $60-$100+ to find all 3�but I only spent about 30 minutes looking; less expensive ones could be lurking out there. Quite honestly, I just don�t care about the price AS LONG AS IT WORKS! If this turns out to work for me (and not only right after I apply it), I would happily buy a bottle every month.My only negative comment right now is about the instructions. It would have been very helpful to say something more like �� a dropper for the whole face and another � a dropper for the whole neck�, or something along the lines. Dime size amount for both is really not useful since most people apply products to those two areas separately. I would also really like to see something about their recommendations of when it should be applied for best results. Which step in your beauty routine? Morning, night or both? Face completely dry or slightly damp?I�m gonna start this manufacturer at 4 stars and give them the benefit of the doubt that their product works. They�re only losing a star for the lack of instructions. And I will come back in 1 or 2 months to post photos and edit as needed for efficacy. First month will be skipped if no real results in pic taken 23 hours after application. Hopefully a more fluid test would be more beneficial to users wondering if they should make the investment or not. ??June 18th Update. Unfortunately, I�m not seeing any results. BUT I haven�t been back to this product page since my initial April 19th review, and I now see they have clearly instructed to use twice a day on a damp skin. That�s probably my issue as I�ve been applying once in the evening on dry skin. Will leave the rating alone for now and try again. Note I�ve only used 1/3 of the contents with my partial neck area, so hopefully can get a better test over the next month doing twice a day without running out.

B
Beachcomber
Hydrating and Gentle, Too Soon for Long-Term Results

I have mature, dry, sensitive skin, and over the past year I have been trying to be more consistent about taking care of it and slowing down the visible signs of aging, even just a little.I have been trying quite a few products, so when I saw this Clinical Resolution Serum, I was interested in the ingredient list. Sodium hyaluronate is always a plus for hydration, and panthenol is great for helping with dryness and supporting the skin barrier. Acetyl hexapeptides were new to me, and are supposed to help improve the look of fine lines over time. I also like that this product is cruelty-free and made in the USA.I have been using it morning and night for about a week, applying two to three drops and gently rubbing it into my skin. One thing to note is that it is meant to be used on damp skin, which is a little different from some other serums. At night, I apply it right after washing, and in the morning I use it after rinsing my face.The serum has no noticeable scent, which I appreciate, and I have had no irritation or sensitivity issues. It absorbs quickly and does not leave any sticky or greasy residue.So far, my skin feels nicely hydrated and looks a bit more refreshed after applying it, especially when followed with a moisturizer. I have not noticed much change in fine lines yet, but after only a week, I would not expect to.Overall, this feels like a well-formulated, higher-end serum that is pleasant to use and gentle on my skin. The price is on the higher side, so I would want to see more noticeable results over time, but I am interested to keep using it and see how it performs.

S
SarahLT
Good brightening serum but overpriced

This hyaluronic peptide serum from Clinical Resolution is clear and lightweight with a slightly oily feel that is super silky on the skin and absorbs very quickly without leaving the skin sticky or oily.With niacinamide, alpha-arbutin, and licorice root extract, this is a nicely formulated brightening serum. While it does contain magnesium ascorbyl phosphate - a vitamin c derivative - it requires conversion in the skin and is much less potent than l-ascorbic acid (true C) that is used in specific vitamin C serums. So the heavy hitters for brightening are niacinamide, alpha-arbutin, and licorice.I love that there are soothing ingredients and that there are a lot of peptides which are great for reducing fine lines and wrinkles over time.One thing to note is that acetic acid is the second ingredient which is high on the list. It helps balance the ph level of the serum which is important and it can also be mildly exfoliating, although not like AHAs. Sensitive skin folks should use cautiously as first.I�ve been using it for a few days and notice an increased level of hydration and a slight decrease in inflammation. The benefits from the peptides could take 4-8 weeks but it�s a potent blend so it should deliver.My only objection is the high price tag. I�ve been using and reviewing skincare products for some time now and have used very similar formulas for much less. These are no longer unique ingredients and are widely used so I feel like the price should be adjusted to be competitive.

A
Amazon C.
Amazing ingredients for anti-aging

I like this product because it's like an all-in-one serum since it contains Hyaluronic acid and panthenol for hydration, vitamin c for brightening, peptides for anti-aging, and more. I think the star ingredient in this serum is the acetyl-hexapeptide because it can actually work almost like botox, and relax your muscles, leading to reduction in wrinkles.I have used this serum for about a week now, every other day, and it may be too early to see drastic results but I am liking how it makes my skin feel after using. I apply it after applying toner, and it glides on smoothly and absorbs quickly. The texture of the serum is lightweight and has no added fragrance. My skin feels soft, hydrated, and more evenly toned, no tackiness, or heavy oily feeling.I've never seen a serum with such a high quality ingredient list and I think this is the reason why the price is so high. There are many anti-aging, anti-inflammatory, barrier protecting, hydrating ingredients in this serum! Honestly, I can't say whether it is worth it or not because I haven't used it long enough but I would say that if you can afford it, give it a try.

C
Customer R.
Has already started to work for my fine lines!

The Clinical Resolution hyaluronic acid vitamin C serum really does work especially for my fine lines! I've been using it for a little while now and although I had to initially research the proper order of when to apply the serum compared to some other facial moisturizers and sunscreen, I've now since learned. I have started to definitely notice a difference on the fine lines.As for thicker wrinkles or deeper wrinkles, I haven't noticed any significant difference just yet but that may be because I haven't used it for a long enough period of time. There is a very clear difference in fine lines and wrinkles. I'm actually surprised at how well it's working because I didn't expect it to do so much in such a short amount of time.This dropper is very easy to use and apply to your face and a little product goes a long way! I didn't experience any burning or anything like that so either I have thick skin or maybe I applied less than some other people but I had no issues with how it felt on my skin. I actually felt that it was moisturizing and they felt that it was quite light overall. No issues with putting it on and then immediately going outside either. I live in a climate that can get quite warm and is always sunny so it's not like there was always cloud cover or anything like that protecting me from the sun. On many occasions I put on the serum without sunscreen and went outside during my day. No issues with anything to that end either.In terms of value for money I think that this is decent value for more premium skin care. I'm now starting to get more into skin care and making sure that my skin is hydrated and treated well. I have noticed that you have a spectrum of pricing; however now that I know that this works for me I'm much more likely to get more because even though the pricing is more on the premium side, for the quantity that you get, I know that it works for me.

B
Barbara W. (United States)
If you want great skin...

Try it!

O
Olivia F.
Good for all skin types

It works well for both me and my friend, even though our skin is totally different. It's gentle, hydrating, and works great for all skin types.

H
Hannah W.
Skin is firmer

I've noticed my skin is firmer and feels moisturized. It's helping with the fine lines around my eyes, too.

R
Rebecca H.
Skin feels lifted

My skin feels lifted and firmer. I've been using this for a month now, and it really makes a difference in how my skin feels!

A
Amanda T.
Protects my skin

I use this serum as a protective barrier from all the environmental stressors. It feels like a shield for my skin.

S
Sarah W.
Glowy skin

My skin has a nice glow to it after using this serum. I can see a huge improvement in my skin texture and appearance.

T
Tessa R.
Hydrates without greasiness

This serum keeps my skin hydrated without that heavy, greasy feeling. It's perfect for my combo skin!

O
Olivia B.
Redness is way down

This serum has been so good for my redness. It's soothing and calms my skin down without irritating it.

L
Lauren V.
Bouncy skin!

After using this for a week, my skin feels bouncier and looks fresher. Hydration is on point, too!

Z
Zoe L.
Skin feels plumper

My skin looks a lot plumper after using this serum, especially around my eyes. A definite must-try if you want younger-looking skin.

E
Ella N.
Skin looks so healthy

My skin looks way healthier since I started using this. It's glowing! Feels much smoother too. I'll keep using it.

S
Sophie B.
Can't get enough!

This serum is amazing. My skin has never felt so smooth, and it's been helping with some dry patches I had. So happy with it!

C
Chloe P.
Anti-aging effect

I can feel this tightening my skin a bit. It's also making my fine lines less noticeable. Definitely seems to have anti-aging benefits!

K
Kate D.
My skin is so soft!

I've been using this for a couple of weeks now and my skin feels so soft and smooth. A little goes a long way.

N
Natalie A.
Smoother skin

Been using this for about a week now, and my skin's texture is way smoother. Plus, it really helps with the redness around my nose.

L
Lilly H.
So hydrating

This is really good for dry skin. It hydrates well and doesn't make my face feel greasy. Been using it every day now!