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on June 06, 2025

Liposomal Retinol vs. Traditional Retinol: What’s the Difference?

Retinol is an ingredient well known for its anti-aging benefits, but not all retinol products are created equal. 

What is Traditional Retinol?

Traditional retinol is a derivative of Vitamin A, used to stimulate collagen production, decrease wrinkles, and help with textured skin. However, it’s also known for causing irritation, redness, and peeling. This is because retinol can be unstable, easily broken down by air or light, and can sometimes be too harsh for sensitive skin.


 

What is Liposomal Retinol?

Liposomal retinol is an improved version of traditional retinol. It is made by encapsulating it in microscopic lipid bubbles (liposomes). These liposomes act as protective carriers for retinol, improving its delivery to your skin.

Here’s how liposomal retinol works:

  • Liposomes shield the retinol from environmental damage (like light and oxygen).
  • They slowly release retinol over time, rather than all at once.
  • They enhance penetration into the skin’s deeper layers, making the retinol more effective.

 

Key Differences at a Glance

Feature Traditional Retinol Liposomal Retinol
Stability Less stable, breaks down easily Protected by liposomes, longer shelf life
Delivery Sits more on the surface of the skin Penetrates deeper layers
Irritation Potential Higher risk of irritation and peeling Gentler, slow release to minimize irritation
Effectiveness Effective but can cause dryness More effective at lower doses, better for sensitive skin

 

Benefits of Liposomal Retinol

More Gentle on Skin – Reduced irritation means you can enjoy retinol’s benefits without as much dryness or redness.

More Effective Results – Enhanced penetration means you may see better results for fine lines and skin texture.

Ideal for Sensitive Skin – Those who couldn’t tolerate traditional retinol may find liposomal formulations to be more skin-friendly.


 

Is Liposomal Retinol Right for You?

CRL Age Defying Liposomal Retinol Serum in hands White background

If you’re new to retinol or have sensitive skin, liposomal retinol can be a great starting point. Even if you’re already a retinol pro, liposomal delivery can boost effectiveness and comfort.

At Clinical Resolution Lab, our Age-Defying Liposomal Retinol Serum and Moisturizer are made to provide all these benefits in a gentle, clinically-proven formula.


 

Final Thoughts

Traditional retinol and liposomal retinol both have a place in skincare, but liposomal technology offers a more advanced, skin-friendly approach. 


 

FAQs

Q: Can liposomal retinol be used every day?
A: It depends on your skin’s tolerance! Start with 2-3 times per week and gradually increase.

Q: Does liposomal retinol need to be used at night?
A: Yes, retinol can increase sun sensitivity, so nighttime use is best. Always wear SPF during the day.