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SCIENTIFIC CLINICAL TRIAL
The DNA Essential Mask System ¢â Improves Photoaged Skin
There are a number of products such as alpha-hydroxy acid and retinoic acid derivatives that have been shown to reverse the effects of photo damage and to improve the cosmetic appearance of the skin. The efficacy of topical The DNA Essential Mask System ¢â in treating photo aging is well-established in vitro study. This study was conducted to verify and assess the effect of The DNA Essential Mask System ¢â on photo damaged human skin. The DNA Essential Mask System ¢â is supposed to improve the cosmetic appearance of the skin -namely to reduce or eliminate abnormal pigmentation, and to decrease skin wrinkles. Essentially, all rejuvenation preparations have ingredients that bleach brown pigmentation. It appears that the decrease in skin wrinkles is due to new collagen production according to an in vitro study done by an independent laboratory (Advanced Tissue Sciences).
The purpose of this study was to determine whether the decrease in skin wrinkles observed after treatment with The DNA Essential Mask System ¢â was due to new collagen production or sub clinical irritation.
The clinical trial divided participants into two groups. The subjects were evaluated 24 hours after product application. An independent laboratory tested for increased collagen production by measuring for changes in the levels of the collagen building block proline, which is considered a marker for heightened collagen production.
- Quantitative measurement of skin thickness by high frequency ultrasonography on human skin.
- Qualitative analysis of The DNA Essential Mask System ¢â on subject for overall cosmetic improvement, irritation study, decrease in the number of wrinkles, decrease in the amount of hyper pigmentation by the duration completed
Inclusion / Exclusion:
- The open label, six week pilot study involved 15 women between the ages of 28 and 56.
- All patients were in good general health and had moderate amounts of clinically diagnosed actinic damage, brown spots, and fine wrinkles.
- Women who were using Retin-A or other chemical peel or rejuvenating cream at present or in the past three months were excluded from the study.
Method:
At the initial baseline visit and then weekly;
- Patients stopped using all topical medication for two weeks prior to the study.
- The DNA Essential Mask System ¢â was applied to the skin.
- At the end of the study, participants were asked to complete a questionnaire and to rate the efficacy of the product for qualitative evaluation.
The protocol had been approved by our institutional review board (Ball Memorial Hospital, Research Department, 2401 University Avenue Muncie, IN 47303-3499) and informed consent was obtained from all patients. Furthermore, a key component of the study for quantitative analysis was the use of high frequency ultrasound (20Mhz and above) ultrasonography to measure the effect of The DNA Essential Mask System ¢â on epidermal thickness. High frequency ultrasonography is an advanced bioengineering technique designed specifically for examination of the skin.
Participants were divided into two groups. Nine participants were measured at the initiation of the study and then remeasured 24 hours after the application of The DNA Essential Mask System ¢â The second groups, consisting of six participants, were measured upon the initiation of the study and again at two weeks, four weeks, and six weeks.
The clinical testing revealed that:
- The DNA Essential Mask System ¢â stimulates an increase in dermal proline levels and extensive new collagen production. After six weeks of regular treatment, the average increase in epidermal thickness, in both groups, measured by high frequency ultrasound, was 8%.
- The DNA Essential Mask System ¢â provides optimum skin nutrition to maintain healthy skin rejuvenation.
- The DNA Essential Mask System ¢â becomes continually more effective as skin matures.
Clinical study participants cited the following observations at the conclusion of the six week study:
- 0% - confirmed there was no product sensitivity: Zero side effect!.
- 97% - stated their overall cosmetic appearance had improved.
- 97% - stated the visibility of their pores decreased.
- 97% - stated the incidence of acne decreased.
- 72% - stated the appearance of wrinkles decreased.
- 63% - stated the appearance of irregular skin blemishes decreased.
Ball Memorial Hospital is a regional medical referral center and teaching hospital serving a seven-county area in East Central Indiana. It has 436 operating beds, 2,400 employees and more than 250 physicians on its Clinical Staff, trained in 26 recognized medical specialties. A teaching facility, Ball Hospital is affiliated with Indiana University School of Medicine and is the largest teaching center outside of Indianapolis with 64 physicians involved in family practice, internal medicine, pathology and flexible residencies and a sports medicine fellowship program.
Ball Memorial Hospital is a regional medical referral center and teaching hospital serving a seven-county area in East Central Indiana. It has 436 operating beds, 2,400 employees and more than 250 physicians on its Clinical Staff, trained in 26 recognized medical specialties. A teaching facility, Ball Hospital is affiliated with Indiana University School of Medicine and is the largest teaching center outside of Indianapolis with 64 physicians involved in family practice, internal medicine, pathology and flexible residencies and a sports medicine fellowship program.
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